Testosterone Undecanoate
Cas No 5949-44-0


 

Systematic (IUPAC) Name

[(8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl] undecanoate

Synonyms:
Testosterone,undecanoate (6CI,7CI,8CI);Undecanoic acid, ester with testosterone (8CI);Andriol;Andriol Testocaps;Nebido;Org 538;Testosterone undecylate;Undestor

Identifiers
CAS number: 5949-44-0
ATC code: G03BA03
PubChem: 65157

Compound
ChemSpider: 43121994

Chemical data
Formula C30H48O3
Mol. mass 456.70032
SMILES eMolecules & PubChem
Molecular Weight: 456.78
 

Pharmacokinetic data
Bioavailability: 7%
Metabolism: Liver, Testis and Prostate
Half-life: 1-12 days
Excretion: Urine


Therapeutic considerations
Pregnancy cat: X (USA), Teratogenic effects
Legal status: Schedule III (USA), Schedule IV (Canada)
Routes: oral,I.V

EINECS: 227-712-6
Density: 1.03 g/cm3
Boiling Point: 550.7 °C at 760 mmHg
Flash Point: 230.3 °C
Safety: Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating vapors

    Testosterone undecanoate also known as testosterone undecylate, Andriol, Undestor, Nebido, Pantestone, Restandol, and Nebido-R is an ester of testosterone which is used for the treatment of male hypogonadism. It is also available in an injectable form (Reandron 1000).

       Andriol, is a version of the anabolic steroid Testosterone Undecanoate developed by the pharmaceutical company Organon. This testosterone preparation is encapsulated and sealed in an oil base in a 40 mg capsule taken orally. According to Organon, this method bypasses the liver, preventing it from being damaged by the liver and from adding damaging stresses to the liver found in other testosterone preparations. It is said to enter the body as a fat through the lymphatic system. Experience from users indicates that in doses of less than 240mg per day, effects are negligible, except at the very onset of use, while even in higher doses, effects are still minimal. It is therefore thought that most of the steroid is somehow not making it into the blood stream.

USES: Testosterone is a naturally occurring androgenic anabolic steroid hormone and is used to treat certain types of breast cancer. This medication is used for hormone replacement in males who are not naturally producing a sufficient amount of testosterone.

HOW TO USE: Take this medication by mouth as directed, usually once or twice a day. This is best taken after a meal to reduce stomach upset. Swallow capsules whole. Try to take this medication at the same time each day so you get in the habit of taking it. Do not increase your dose or take this more often than directed. It will have no greater benefits but the risk of side effects will be increased.

SIDE EFFECTS: Stomach upset, headache or acne may occur as your body adjusts to the medication. Other side effects include increased hair growth on the face or body, anxiety, change in sex drive, sleeplessness, increased urination and depression. Males may experience enlargement of breasts and an increase in the frequency and duration of erections. If any of these effects continue or become bothersome, inform your doctor. Notify doctor if you develop: a skin rash, dark urine, pale stools, yellowing of the eyes or skin, muscle aches, vomiting, swelling hands or feet, difficult urination, breathing trouble. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Before taking this drug, notify your doctor of any disease you have, especially: cancer of the prostate or breast (males), liver problems, kidney problems, heart disease, enlarged prostate, drug allergies. High dosage, long-term use of androgens has been related to liver cancer. Discuss your medicine with your doctor/pharmacist. This drug must not be used during pregnancy. If you become pregnant or think you may be pregnant, inform your doctor immediately. Breast feeding should be avoided while using this medicine. Females should be monitored for signs of virilization, such as deepening of the voice, facial hair, acne, menstrual irregularity, or clitoral enlargement. Consult your doctor promptly if any of these symptoms occur. Use in children should be undertaken with extreme caution due to the possibility this drug may have undesirable effects related to the growth of the child. Geriatric men are at higher risk for developing enlarged prostates or prostate cancer when taking this medication.

DRUG INTERACTIONS: Tell your doctor of any over-the-counter or prescription medication you may take, including: blood thinners (e.g., warfarin), insulin, cyclosporine, other steroids, drugs used for diabetes. Do not start or stop any medicine without doctor or pharmacist approval.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.

NOTES: Serious, life-threatening side effects may result from the misuse or abuse of this medication. This medication must be used only for whom it was prescribed and for the condition for which it was prescribed. Laboratory tests will be done periodically while taking this medication to monitor its effects and prevent side effects.

MISSED DOSE: Try to take each dose at the scheduled time. If you miss a dose, take it as soon as remembered; do not take it if it is near the time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.

STORAGE: Store this medication at room temperature between 59 and 86 degrees F (15 and 30 degrees C) away from heat, light and moisture. Do not store in the bathroom. Keep this and all medications out of the reach of children.


                                  
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